© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

This volume presents the history of Western education through the biographies of some 70 individuals, past and present, who exemplify the education of their times or have made important contributions to the development of educational theory or practice. In so doing, it links major issues and ideas in education to key historical personalities. Each chapter includes substantive background information, a summary, and chapter notes.

"If the twentieth century was characterized by the struggle between freedom and tyranny, the great battle of the twenty-first century, Joan Smith predicts, will be between global capitalism and universal human rights. While acknowledging that there is no easy route to creating a fairer, more humane world, we do, she believes, 'have before us the opportunity to create a new kind of society whose values, because they are based on respect rather than coercion, can truly claim to be (...) more moral than anything that has gone before'."--BOOK JACKET. (shrink)

Mandatory workfare has been the centerpiece of welfare reform in this decade. In 1992-94, there was a pitched legislative battle over mandatory workfare in Vermont. Feminist organizations mobilized to oppose the mandatory work requirement, producing data to substantiate the claims that women's jobs did not pay enough to purchase basic needs for their families, that unemployment remained a serious problem for single mothers, and that in states where workfare had already been adopted, it did not raise families out of poverty. (...) Vermont's original bill was made less punitive for welfare recipients in some significant respects as a result of the debate. (shrink)

The planetary boundaries concept has profoundly changed the vocabulary and representation of global environmental issues. The article starts by highlighting the strengths and weaknesses of planetary boundaries from a social science perspective. It is argued that the growth imperative of capitalist economies, as well as other particular characteristics detailed below, are the main drivers of the ecological crisis and exacerbated trends already underway. Further, the planetary boundaries framework can support interpretations that do not solely emphasize technocratic operational approaches and costs, (...) but also assume that these alone can be the solution. (shrink)

The notion of societal boundaries aims to enhance the debate on planetary boundaries. The focus is on capitalist societies as a heuristic for discussing the expansionary dynamics, power relations, and lock-ins of modern societies that impel highly unsustainable societal relations with nature. While formulating societal boundaries implies a controversial process – based on normative judgments, ethical concerns, and socio-political struggles – it has the potential to offer guidelines for a just, social-ecological transformation.

Joan Robinson was one of the greatest economists of the twentieth century and a fearless critic of free-market capitalism. A major figure in the controversial 'Cambridge School' of economics in the post-war period, she made fundamental contributions to the economics of international trade and development. In Economic Philosophy Robinson looks behind the curtain of economics to reveal a constant battle between economics as a science and economics as ideology, which she argued was integral to economics. In her customary vivid (...) and pellucid style, she criticizes early economists Adam Smith and David Ricardo, and neo-classical economists Alfred Marshall, Stanley Jevons and Leon Walras, over the question of value. She shows that what they respectively considered to be the generators of value - labour-time, marginal utility or preferences - are not scientific but 'metaphysical', and that it is frequently in ideology, not science, that we find the reason for the rejection of economic theories. She also weighs up the implications of the Keynesian revolution in economics, particularly whether Keynes's theories are applicable to developing economies. Robinson concludes with a prophetic lesson that resonates in today's turbulent and unequal economy: that the task of the economist is to combat the idea that the only values that count are those that can be measured in terms of money. This Routledge Classics edition includes a new foreword by Sheila Dow. (shrink)

This introductory article is structured around the following themes: it begins with a brief overview of some important works that have paved the way for the present discussion. This is followed by a critique of the concept of “experience” and the philosophies based on it, that was first presented by feminist thinkers Joan Scott and Judith Butler in the 1980’s. The question this debate poses to the discussions in this book is whether focusing on experience is still a philosophically (...) viable option. After that, the views of Edmund Husserl – often described as “the father of phenomenology” – are presented on the particular themes of motherhood and pregnancy, as it is often overlooked that he had anything to say on the topic. Then follows a short outline of the structure of the experience of pregnancy, and also the modest suggestion that pregnancy should be seen not only as “split subjectivity” but also as a specific mode of phenomenological “in-between.” Thereafter the question is taken up whether pregnancy as a philosophical topic might also affect the methodological core of phenomenology. The article ends with a speculative outlook towards certain themes that have developed as a consequence of thinking pregnancy philosophically. (shrink)

This article will look closely at the performance of tomboy identity in Joan Anim-Addo's collection of poetry Janie, Cricketing Lady, written as a tribute to her mother Jane Joseph, and Margaret Cezair-Thompson's novel The Pirate's Daughter, a fiction about Errol Flynn's ‘outside’ Jamaican daughter, May. It will argue that the ongoing affects of colonialism and patriarchy in the islands of Grenada and Jamaica, respectively, shape the life narratives of Janie and May who express their anger, shame, fear, frustration and (...) desire through their ambiguous gender identity and through their determination to intervene in masculinist traditions, such as cricket, piracy and adventure, traditions that underpin Caribbean his/tories. To understand the way in which affect can be expressed through tomboyism in Caribbean societies, it is necessary to look at colour and class alongside gender in the context of Caribbean creolisation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Being and Time. A Translation of “Sein und Zeit by Martin HeideggerP. Christopher SmithMartin Heidegger. Being and Time. A Translation of “Sein und Zeit. Translated by Joan Stambaugh. Albany: State University of New York Press, 1996. Pp. xix + 487. Paper, $18.95.A new English translation of Heidegger’s best book, Sein und Zeit has been eagerly anticipated ever since the appearance of the Macquarrie/Robinson translation in 1962.1 For (...) anyone with an ear for German would find that, in turning Heidegger’s visceral prose into wooden terminology, this first pathbreaking and very scholarly translation failed completely to render the startling and wholly untraditional diction of this work, a diction that rocked a staid and stifling academia and that in lectures preceding the book’s publication had therefore attracted students in droves, among them Leo Strauss, Hanna Arendt, Hans-Georg Gadamer, Karl Löwith, Herbert Marcuse, and Hans Jonas. At long last, a new translation, Joan Stambaugh’s, is here, but, unfortunately, it is no better in this crucial regard, and it is not as scholarly either. (Macquarrie/Robinson do provide many detailed and useful accounts of their choices of translation.) Indeed, the new translation often seems to be a mere revision of the old and falls into much of the old translation’s terminological uprooting of Heidegger’s sometimes thick but always earthy language. Here are three examples.In S we find this rendering of Heidegger’s preliminary account of the phenomenological method he will apply in “laying out” our “factual” human existence “there” “in the world” of our cooperative taking care of life’s tasks:This “a priori” of the interpretation of Da-sein is not a structure which is pieced together, but rather a structure which is primordially and constantly whole. It grants various perspectives on the factors which constitute it. These factors are to be kept constantly in view, bearing in mind the preceding whole of this structure.(S 37)In M/R this same passage is translated, somewhat more readably and accurately, as:In the interpretation of Dasein, this structure is something ‘a priori’; it is not pieced together, but is primordially and constantly a whole. If affords us, however, various ways of looking at the items which are constitutive for it. The whole of this structure always comes first; but if we keep this constantly in view, these items, as phenomena, will be made to stand out.(M/R 65) [End Page 148]We note, first, how many of the M/R translations are taken over by S: “not a structure... pieced together,” which mistranslates “keine zusammengestückte Bestimmtheit” (SZ 41) or “not a determination arrived at bit by bit,” and “[structure]... primordial(ly) and constant(ly) (a) whole” for “eine ursprünglich und ständig ganze Struktur,” in which the English “primordial” turns the rather ordinary “ursprünglich” or “originally” into a technical term. Indeed, this phrase might best be rendered in more usual English along the lines of “This structure, assumed a priori... is originally, and continues to be, a whole.” For the point, lost in S but preserved in M/R with their “however,” is precisely that even though Dasein has been determined ahead of time to have the basic structure of a whole, we can still elucidate different sides of it phenomenologically by “throwing them into relief” (compare Heideger’s “phänomenal abzuheben”). In S, Heidegger’s pivotal “phänomenal” is lost altogether.Here, next, is how S renders Heidegger’s account of the call of conscience, which calls us back from our having lost ourselves in pressed busyness and vain chattering, at just that moment when these lose all their significance for us and go dead:The call is lacking any kind of utterance. It does not even come to words, and yet it is not at all obscure and indefinite. Conscience speaks solely and constantly in the mode of silence. Thus it not only loses none of its perceptibility, but forces Da-sein thus summoned and called upon to the reticence of itself.(S 252–53).And here is the M/R translation:The call dispenses with any kind of utterance. It does... (shrink)

“Everything is a lie … Nothing is a lie” From reviews: -/- Jan Rabie’s short fiction collection 21 in the sixties was a sign of renewal, and it was the beginning of an era of unprecedented growth in local as well as Afrikaans literature and I hope this book can do the same – Koos Kombuis -/- An artful masterpiece – Anschen Conradie -/- To fly with a solo debut, that Smith does convincingly – Joan Hambidge -/- About: (...) This fictional work explores various philosophical ideas, from AI, climate change justice, technology and its ethical complications, to the ideas of clones and robots and their position in society as, plausibly, citizens with full "human rights". (shrink)

This study considers the potential for influencing business students to become ethical managers by directing their undergraduate learning environment. In particular, the relationship between business students’ academic cheating, as a predictor of workplace ethical behavior, and their approaches to learning is explored. The three approaches to learning identified from the students’ approaches to learning literature are deep approach, represented by an intrinsic interest in and a desire to understand the subject, surface approach, characterized by rote learning and memorization without understanding, (...) and strategic approach, associated with competitive students whose motivation is the achievement of good grades by adopting either a surface or deep approach. Consistent with the hypothesized theoretical model, structural equation modeling revealed that the surface approach is associated with higher levels of cheating, while the deep approach is related to lower levels. The strategic approach was also associated with less cheating and had a statistically stronger influence than the deep approach. Further, a significantly positive relationship reported between deep and strategic approaches suggests that cheating is reduced when deep and strategic approaches are paired. These findings suggest that future managers and business executives can be influenced to behave more ethically in the workplace by directing their learning approaches. It is hoped that the evidence presented may encourage those involved in the design of business programs to implement educational strategies which optimize students’ approaches to learning towards deep and strategic characteristics, thereby equipping tomorrow’s managers and business executives with skills to recognize and respond appropriately to workplace ethical dilemmas. (shrink)

An increasing number of experiments at the Belle, BNL, CERN, DAΦNE and SLAC accelerators are confirming the violation of time reversal invariance (T). The violation signifies a fundamental asymmetry between the past and future and calls for a major shift in the way we think about time. Here we show that processes which violate T symmetry induce destructive interference between different paths that the universe can take through time. The interference eliminates all paths except for two that represent continuously forwards (...) and continuously backwards time evolution. Evidence from the accelerator experiments indicates which path the universe is effectively following. This work may provide fresh insight into the long-standing problem of modeling the dynamics of T violation processes. It suggests that T violation has previously unknown, large-scale physical effects and that these effects underlie the origin of the unidirectionality of time. It may have implications for the Wheeler-DeWitt equation of canonical quantum gravity. Finally it provides a view of the quantum nature of time itself. (shrink)

T violation has previously been shown to induce destructive interference between different paths that the universe can take through time which leads to a new quantum equation of motion called bievolution. Here we examine further details of the interference and clarify the conditions needed for the bievolution equation.

Much space is devoted by Broadhead to the discussion of this strophe and its ‘various difficulties’. The discussion centres on two main issues: 1. ‘If the Chorus say ; that implies there has already been some call he might have heard & But to Darius there has been no appeal at all; nor surely could the previous invocation have been described in these excessive epithets.’ So Headlam,3 who then proceeded, in the light of Luc. Necyom.

The paper presents the outlines of an ontology of plans and guidelines, which is then used as the basis for a framework for implementing guideline-based systems for the management of workflow in health care organizations. The framework has a number of special features, above all in that it enables us to represent in formal terms assignments of work-items both to individuals and to teams and to tailor guideline to specific contexts of application in health care organizations. It is designed also (...) to enable implementations to do justice to the fact that the processes carried out in health care organizations may deviate in different ways from the norms set forth in corresponding guideline definitions. This means that implementations built in conformity with the framework will be marked by a type of flexibility that might make them more likely to be accepted by healthcare professionals than are standard guideline-based management systems. (shrink)

Deep Brain Stimulation is an invasive device-based neuromodulation technique that allows the therapeutic direct stimulation of subcortical and deep cortical structures following the surgical placement of stimulating electrodes. DBS is approved by the U.S. Federal Drug Administration for the treatment of movement disorders and obsessive-compulsive disorder, while new indications, including Major Depressive Disorder, are in experimental development. We report the case of a patient with MDD who received DBS to the ventral internal capsule and ventral striatum bilaterally and presented with (...) 2 weeks of voltage-dependent Tourette-like symptoms including brief transient episodes of abrupt-onset and progressively louder coprolalia and stuttered speech; tic-like motor behavior in his right arm and leg; rushes of anxiety, angry prosody, angry affect; and moderate amnesia without confusion. We describe the results of the inpatient neuropsychiatric workup leading to the diagnosis of iatrogenic voltage-dependent activation of cortico-subcortical circuits and discuss insights into the pathophysiology of Tourette as well as safety considerations raised by the case. (shrink)

The popular view of non-directive genetic counseling limits the counselor's role to providing information to clients and assisting families in making decisions in a morally neutral fashion. This view of non-directive genetic counseling is shown to be incomplete. A fuller understanding of what it means to respect autonomy shows that merely respecting client choices does not exhaust the duty. Moreover, the genetic counselor/client relationship should also be governed by the counselor's commitment to the principle of beneficience. When non-directive counseling is (...) reexamined in light of both these principles, it becomes clear that there are cases in which counselors should attempt to persuade clients to reconsider their decisions. Such attempts are consistent with non-directive counseling because, while respecting the clients' decision-making authority, they insure that clients act with full knowledge of the moral consequences of their decisions. (shrink)

v. 1. Nicomachean ethics. Politics. The Athenian Constitution. Rhetoric. On Poetics.--v. 2. Logic.--v. 3. Physics. Metaphysics. On the soul. Short physical treaties.--v. 4. On the heavens. On generation and corruption. Meteorology. Biological treatises.

In this paper, we present the results of two surveys that investigate subjects’ judgments about what can be known or justifiably believed about lottery outcomes on the basis of statistical evidence, testimonial evidence, and “mixed” evidence, while considering possible anchoring and priming effects. We discuss these results in light of seven distinct hypotheses that capture various claims made by philosophers about lay people’s lottery judgments. We conclude by summarizing the main findings, pointing to future research, and comparing our findings to (...) recent studies by Turri and Friedman. (shrink)

The notion of risk plays a central role in economics, finance, health, psychology, law and elsewhere, and is prevalent in managing challenges and resources in day-to-day life. In recent work, Duncan Pritchard (2015, 2016) has argued against the orthodox probabilistic conception of risk on which the risk of a hypothetical scenario is determined by how probable it is, and in favour of a modal conception on which the risk of a hypothetical scenario is determined by how modally close it is. (...) In this article, we use Pritchard’s discussion as a springboard for a more wide-ranging discussion of the notion of risk. We introduce three different conceptions of risk: the standard probabilistic conception, Pritchard’s modal conception, and a normalcy conception that is new (though it has some precursors in the psychological literature on risk perception). Ultimately, we argue that the modal conception is ill-suited to the roles that a notion of risk is required to play and explore the prospects for a form of pluralism about risk, embracing both the probabilistic and the normalcy conceptions. (shrink)

Our commentary outlines a number of arguments questioning an autonomous model of word recognition without feedback. Arguments are presented against the need for a phonemic decision stage and in support of a featural level in a model including feedback.

High‐fidelity binding of transcription factors (TFs) to DNA target sites is fundamental for proper regulation of cellular processes, as well as for the maintenance of cell identity. Recognition of cognate binding motifs in the genome is attributed by and large to the DNA binding domains of TFs. As an additional mode of conferring binding specificity, noncoding RNAs (ncRNAs) have been proposed to assist associated TFs in finding their binding sites by interacting with either DNA or RNA in the vicinity of (...) their target loci. However, a well‐documented example of such a mechanism was lacking until we recently reported that a ncRNA made by Epstein‐Barr virus uses an RNA–RNA interaction with nascent transcripts generated from the viral genome to facilitate the recruitment of an interacting TF, PAX5, to viral DNA. This proof‐of‐principle finding suggests that cellular ncRNAs may likewise function in guiding interacting TFs to chromatin target sites. (shrink)

We describe and analyze 13 cases handled by our ethics consultation service (ECS) in which families requested continuation of physiological support for loved ones after death by neurological criteria (DNC) had been declared. These ethics consultations took place between 2005 and 2013. Patients’ ages ranged from 14 to 85. Continued mechanical ventilation was the focal intervention sought by all families. The ECS’s advice and recommendations generally promoted “reasonable accommodation” of the requests, balancing compassion for grieving families with other ethical and (...) moral concerns such as stewardship of resources, professional integrity, and moral distress. In cases we characterized as finitegoal accommodation, a “reasonable accommodation” strategy proved effective in balancing stakeholders’ interests and goals, enabling steady progress toward resolution. When a family objected outright to a declaration of DNC and asked for an indefinite accommodation, the “reasonable accommodation” approach offered clinicians little practical direction, and resolution required definitive action by either the family or the clinical team. Based on our analysis and reflections on these 13 cases, we propose ethically justified and practical guidelines to assist healthcare professionals, administrators, and ECSs faced with similar cases. (shrink)

This thought-provoking text explores the ethical dimensions of the professional nursing practice. The authors discuss important topics such as inter-professional relationships, collective action, nursing research, and educational requirements within the context of professional commitment. Providing a balance between an empirical and a philsophical framework, the book stimulates the reader to ponder, analyze and evaluate the professional and ethical aspects of these issues.

Scientific experts have confirmed that anthropogenic warming is underway, and some degree of adaptation is now unavoidable. However, the details of impacts on the scale of climate change at which humans would have to prepare for and adjust to them are still the subject of considerable research, inquiry, and debate. Planning for adaptation requires information on the scale over which human organizations and institutions have authority and capacity, yet the general circulation models lack forecasting skill at these scales, and attempts (...) to “downscale” climate models are still in the early stages of development. Because we do not know what adaptations will be required, we cannot say whether they will be harder or easier—more expensive or less—than emissions control. Whatever improvements in regional predictive capacity may come about in the future, the lack of current predictive capacity on the relevant scale is a strong argument for why we must both control greenhouse gas emissions and prepare to adapt. (shrink)